Microbiological Spectrum, Antibiogram and Bacteraemia in Biliary Tract Infections- A Study from Tertiary Centre of North India

Objectives: The present study was undertaken to understand the microbiological profile, clinical presentation, associated bacteraemia and antibiogram pattern of various isolates from patients with biliary tract infection admitted in a tertiary care centre India.
 Methods: In this retrospective study, Bile samples were collected adult our hospital processed as per standard protocol. results interpreted Clinical Laboratory Standards Institute (CLSI) 2020 guidelines. Bacterial categorised MDR PDR CDC.
 Results: 326 bile sent for aerobic culture susceptibly testing. 197 (60.42%) these culture-positive, remaining 129 (39.57%) sterile nature. A total 289 pathogens isolated; Escherichia coli (37.37 % n=108) predominant, followed by Klebsiella pneumoniae (25.60%, n=74). 170 (60.49%) resis­tant 111 (39.50%) susceptible drugs tested. 27 ESBL producing strains E.coli( n= 20) spp (n= 7) 21 CRE E ( 12) spp( n=9) reported . 5 Klebsie­lla spp. single E.coli colis­tin (MIC =0.5 mcg/ml) microbroth dilution test.
 Conclusion: soaring rates mainly gram-negative bacteria are red flag emergence multidrug resistant organisms change anti-microbiological spectrum infections, there is an urgent need empirical prophylactic an­timicrobial therapy every setting.